Cyp2c19 polymorphisms in asians

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More than 30 years of genetic research on the CYP2C19 gene alone has identified approximately 2, reference single nucleotide polymorphisms rsSNPs containing 28 registered alleles in the P Allele Nomenclature Committee and the number continues to increase. Functional information on the variant is essential for justifying its clinical use. Discovery of new genetic variants is outstripping the generation of knowledge on the biological meanings of existing variants.

How to cite this article. Oman Med J Jul; 28 4 How to cite this URL.

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The CYP2Cs also metabolize some endogenous compounds such as arachidonic acid. Each member of this subfamily has been found to be genetically polymorphic. The most well-known of these polymorphisms is in CYP2C

CYP2C19 belongs to the cytochrome P superfamily of enzymes involved in activating and detoxifying many carcinogens and endogenous compounds, which has attracted considerable attention as a candidate gene for digestive system cancer. In the past decade, the relationship between CYP2C19 polymorphism and digestive system cancer has been reported in various ethnic groups; however, these studies have yielded contradictory results. To clarify this inconsistency, we performed this meta-analysis. In total, 18 studies with 4, cases and 6, controls were included.

Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity. Many pharmacologically-relevant polymorphisms do show variability among different populations.

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This is an open access article distributed under the terms of Creative Commons Attribution License. The cytochrome P enzymes have an important role in the metabolism of various therapeutic agents, in which different enzymatic activities lead to variability in drug responses among individuals 1. Cytochrome P 2C19 CYP2C19 is a highly polymorphic isoenzyme of the cytochrome P superfamily, affecting the metabolism of an extensive range of therapeutic drugs 2.

Tropical Diseases pp Cite as. The genetic polymorphism of drug-metabolizing enzymes has a major influence on the fate of xenobiotic substances, whether as drugs or absorbed from the environment. Our understanding of this polymorphism is important in order to evaluate the genetic predisposition for exposure-related risks and, in the future, to develop individualized drug therapy.

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This proteina member of the cytochrome P mixed-function oxidase system, is involved in the metabolism of xenobioticsincluding many proton pump inhibitors and antiepileptics. The gene encodes a member of the cytochrome P superfamily of enzymes. These proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many drugs.

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Genetic variation in the cytochrome P 2C19 CYP2C19 gene has been documented gradually as the determinant conversion and variability in the antiplatelet effect of clopidogrel. A total of 1, Thai patients participated in this study. Genotypes for CYP2C19 polymorphisms were detected by the microarray-based technique.

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