Mmp9 breast

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Matrix metalloproteinases MMPs are endopeptidases with the ability to degrade extracellular matrix proteins. In healthy individual tissue disruption is prevented by precised regulation of MMPs; however, in cancer a number of MMPs are overexpressed causing tissue disruption and making tumor cells capable of invasion and metastasis. Materials and Methods: We performed a transcriptomic profiling of 38 surgically-resected breast tumors 4 G1, 17 G2 and 17 G3 using Affymetrix Gene 1.

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Metrics details. A total of TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were included in this study. Of the patients, Univariate and multivariate analyses revealed that the relative change in sMMP-9, rather than sMMP-9 at baseline or surgery, had a remarkable predictive value for pCR.

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The discovery and development of anticancer still remain a challenge especially regarding the problem of cancer cell selectivity. Matrix metalloproteinase MMP was broadly studied as one of the protein targets to stop cancer angiogenesis as well as its cell migration. The MMP degrades extracellular matrix ECM such as collagen and gelatin which are important to control the cell migration from one to other sites.

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Silibinin is the main component of the silymarin complex and is isolated from the seeds of Silybum marianumalso known as milk thistle 1. Silibinin has a wide range of pharmacologic effects including the induction of apoptosis, and the inhibition of cell proliferation, cell invasion and angiogenesis 23. Recently, Kim et al reported that silibinin triggers cell cycle arrest through the downregulation of cyclin B1 and cdc2 and upregulation of p21 expression in triple-negative breast cancer cells 4.

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The relationship between the expression levels of matrix metalloproteinase-2 MMP-2 and MMP-9 and breast cancer prognosis was studied. Breast cancer tissue samples from 80 patients and tumor-adjacent normal tissue samples from 40 patients were collected, and MMP-2 and MMP-9 expression in these samples were examined using immunohistochemistry IHC. The relationship of MMP-2 and MMP-9 expression levels with breast cancer patient clinicopathological parameters and prognosis was analyzed.

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Organization into polarized three-dimensional structures defines whether epithelial cells are normal or malignant. Induction of Raf or activation of an engineered, functionally inducible MMP9 in nonmalignant cells led to loss of tissue polarity, and reinitiated proliferation. Conversely, inhibition of Raf or MMP9 with small molecule inhibitors or shRNAs restored the ability of cancer cells to form polarized quiescent structures.

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There is currently a great interest in identifying cancer biomarkers and signalling pathways mechanistically related to breast cancer progression. Matrix metalloproteinase-9 MMP-9 is a member of matrix degrading enzymes involved in cancer development, invasion and metastasis. Our objective was to investigate MMP-9 expression in normal human breast tissue and to compare it to that of breast cancer of various histological grades and molecular subtypes.

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Zinc is the catalytic component of proteins that regulate responses to DNA damage, intracellular signaling enzymes, and matrix metalloproteinases, which are important proteins in carcinogenesis. The objective of this review is to bring current information on the participation of zinc and matrix metalloproteinases types 2 and 9 in mechanisms involved in the pathogenesis of breast cancer. We conducted a literature review, in consultation with the PubMed, Lilacs, and Scielo databases.


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